论文部分内容阅读
目的:探索血管紧张素转换酶(ACE)基因I/D和血管紧张素Ⅱ受体1(AT1R)基因A1166C多态性与高血压性脑卒中的关系和两基因之间的作用对高血压性脑卒中发病的影响。方法:我们用PCR的方法检测86例缺血性脑卒中病人,51例高血压病人和58例正常人的ACE I/D和AT1R A1166C多态性。结果:高血压性脑卒中组的ACE DD型基因和D等位基因的频率高于高血压性非卒中组。同样,高血压性脑卒中的AT1R AC+CC型基因和C等位基因和频率也高于高血压非卒中组。结论:ACE DD基因和C等位基因、AT1R AC CC型基因和C等位基因是高血压性脑卒中的危险因子。
Objective: To explore the relationship between angiotensin converting enzyme (ACE) gene I / D and angiotensin Ⅱ receptor 1 (AT1R) gene A1166C polymorphism and hypertensive stroke and the role of the two genes in hypertensive The impact of stroke. Methods: We used polymerase chain reaction to detect ACE I / D and AT1R A1166C polymorphisms in 86 ischemic stroke patients, 51 hypertensive patients and 58 normal controls. Results: The frequency of ACE DD genotype and D allele in hypertensive stroke group was higher than that in hypertensive non-stroke group. Similarly, the AT1R AC + CC genotype and C allele and frequency in hypertensive stroke were also higher than those in the non-stroke hypertensive group. CONCLUSIONS: The ACE DD and C alleles, AT1R AC CC and C alleles are risk factors for hypertensive stroke.