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Ghrelin是近年发现的一种胃肠激素，具有多种生物学作用，对机体的功能发挥广泛的影响。大量研究表明Ghrelin与肝脏急慢性损伤密切相关，其可以通过改善炎症反应、降低氧化应激、减少细胞凋亡等发挥保护肝脏的作用。现对Ghrelin在急慢性肝损伤中的保护作用的研究进展进行综述。“,”Ghrelin has been discovered as a kind of gastrointestinal hormone in recent years, which poses a variety of biological functions and has a wide range of functional effects on the body. Numerous studies have revealed that ghrelin are actively engaged to protect the liver by improving inflammatory response, reducing oxidative stress, and apoptosis in acute and chronic liver injury. This article summarizes the research progress of the protective effect of ghrelin for acute and chronic liver injury.