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目的探讨急性脑梗死患者监测血清C反应蛋白(CRP)的临床意义。方法监测98例急性脑梗死患者血清CRP浓度的动态变化。同时比较不同梗死面积组、不同病情严重程度组的CRP水平,并对CRP水平与神经功能缺失程度评分(NDS)的相关性进行评价。结果①血清CRP浓度:大小梗死灶组显著高于腔隙性脑梗塞组(P<0.01),大梗死灶组显著高于小梗死灶组(P<0.05)。②脑梗死患者依病情轻、中、重程度不同,血清CRP水平依次增高(P<0.01)。③CRP水平在发病后24h至28d明显升高,血清CRP浓度与NDS评分呈正相关;24～48h相关性显著(P<0.01),随病程延长相关性逐渐减弱(P<0.05)。结论脑梗死与CRP水平密切相关,血清CRP水平越高,病情越严重,预后越差。血清CRP水平可作为脑梗死的危险预测因子,是判断病情严重程度和预后的一个客观指标。
Objective To investigate the clinical significance of monitoring serum C-reactive protein (CRP) in patients with acute cerebral infarction. Methods The dynamic changes of serum CRP levels in 98 patients with acute cerebral infarction were monitored. CRP levels in different infarct size groups and different severity groups were also compared, and the correlation between CRP level and neurological deficit score (NDS) was evaluated. Results ① Serum CRP concentration: the size of infarction group was significantly higher than that of lacunar infarction group (P <0.01), and the extent of CRP in infarction group was significantly higher than that of small infarction group (P <0.05). ②In patients with cerebral infarction, the level of serum CRP increased in turn according to the mild, moderate and severe degree of illness (P <0.01). (3) The level of CRP increased significantly from 24h to 28d after onset, and the serum CRP level was positively correlated with NDS score. The correlation was significant at 24-48h (P <0.01), and gradually decreased with the prolongation of course (P <0.05). Conclusions Cerebral infarction is closely related to the level of CRP. The higher the serum CRP level, the more severe the disease and the worse the prognosis. Serum CRP level can be used as a risk factor for cerebral infarction, is to determine the severity and prognosis of an objective indicator.