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了解地鼠肾细胞狂犬病纯化疫苗接种安全性及有效性。分别以 1.0ml及 0 .5ml的剂量 ,按暴露后及暴露前免疫程序给 313人接种 ,用小鼠中和试验法检测血清中和抗体效价。结果显示 :临床副反应轻微 ,副反应率为0 .89%～ 15 % ;免疫全量疫苗和半量疫苗的人群均获保护力 ,抗体阳转率为 10 0 % ,免后抗体GMT滴度分别为35 .2IU/ml(n =32 )和 31.4IU/ml(n =37) ,经检验两组无显著性差异 (P>0 .0 5 ) ;免疫全量疫苗和半量疫苗两组的免疫前、后相比 ,经检验有显著性差异 (P <0 .0 5 ) ,表明疫苗安全有效
To understand the safety and efficacy of hamster kidney cell rabies vaccination. The mice were inoculated with 313 doses of 1.0ml and 0.5ml respectively according to the immunization schedule after exposure and before exposure. The neutralizing antibody titers of the serum were tested by mouse neutralization test. The results showed that the clinical side effects were mild and the rate of side-effects was 0.89% -15%. The population immunized with full dose vaccine and half dose vaccine were protected, the rate of positive antibody was 100%, and the GMT titers of free antibody were 35.2 IU / ml (n = 32) and 31.4 IU / ml (n = 37). There was no significant difference between the two groups after immunization (P> 0.05) After comparison, the test showed significant difference (P <0. 05), indicating that the vaccine is safe and effective