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对１０名男性受试者单剂量ｐｏ２４０ｍｇＶｅｒ缓释片药代动力学及心电图变化进行研究。血药浓度—时间数据用零级吸收过程的一室模型拟合，其药代动力学参数：Ｔｍａｘ５．９±１．６ｈ；Ｃｍａｘ１１８．９±３７．２μｇ·Ｌ－１；Ｔ１５．４±１．５ｈ；ｋ０３０．５±１７．５μｇ·Ｌ－１·ｈ－１；Ｔ１／２１０．８±４．９ｈ。ＰＲ间期延长有显著意义，血药浓度与ＰＲ间期变化满足Ｓ型模型，其药效学参数：ＥＣ５０６４．６±１６．９μｇ·Ｌ－１；Ｅｍａｘ５４±１１ｍｓ；ｓ１．６８±０．６６
Pharmacokinetic and electrocardiographic changes of a single dose of po240mg Ver sustained-release tablets in 10 male subjects were studied. The plasma concentration-time data were fitted by a one-compartment model of the zero-order absorption process with pharmacokinetic parameters: Tmax 5.9 ± 1.6 h; Cmax 118.9 ± 37.2 μg · L -1; T 15.4 ± 1 .5h; k030.5 ± 17.5μg · L-1 · h-1; T1 / 210.8 ± 4.9h. PR interval prolonged significance, plasma concentration and PR interval changes to meet the S-type model, the pharmacodynamic parameters: EC5064.6 ± 16.9μg · L-1; Emax54 ± 11ms; s1.68 ± 0. 66