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棉酚对人类的抗生育效果达99％,精子细胞和粗线初级精母细胞对棉酚最为敏感。棉酚可使大鼠精子尾部损伤,出现局部纤维崩解和尾巴弯曲。已知精子头部形态由多基因控制,诱变剂可引起精子头部形态异常,分析精子头部形态改变已成为检验药物对生精细胞遗传效应的敏感指标。Amés试验及对体内、外淋巴细胞染色体影响的研究表明,棉酚既不是诱变剂、致畸剂,亦非致癌物。本文用银染法观察喂服棉酚一年半小鼠及志愿服棉酚者的精子头部形态,以进一步探讨棉酚对生殖细胞有否遗传效应,为其安全使用提供理论依据。
Gossypol on human anti-fertility effect of 99%, spermatocytes and thick primary spermatocytes are most sensitive to gossypol. Gossypol causes damage to the sperm tail in rats with local disintegration and tail bending. Known sperm head morphology controlled by multiple genes, mutagens can cause abnormal sperm head morphology, analysis of sperm head morphological changes has become a test drug spermatogenic cells genetic susceptibility indicators. Amés test and studies on the effects of chromosomes in the body and peripheral lymphocytes have shown that gossypol is neither a mutagen, a teratogen, nor a carcinogen. In this paper, silver staining was used to observe the sperm head morphology of gossypol fed with gossypol for one and a half years and volunteer gossypol to further investigate whether gossypol has a genetic effect on germ cells and provide a theoretical basis for its safe use.