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日本最早在1914年生产合成茜素。自此以后,染料工业发展很快,至1938年日本已成为世界第四位染料生产国。第二次世界大战时期产量减少,1953年恢复到战前水平,联苯胺产量持续增长,劳动条件十分恶劣,工人急性膀胱炎或血尿屡有报导。第二次世界大战后的十年,膀胱癌病例逐渐增加。在1948年,职业性膀胱癌作为产业工人的健康问题开始引起社会的关注,日本通商产业省指定一个委员会对染料工业进行了调查,1955年开始改
Japan first produced synthetic alizarin in 1914. Since then, the dye industry has developed rapidly, and by 1938 Japan had become the fourth dye producing country in the world. During the Second World War, the output decreased, and the level of pre-war restoration was restored in 1953. The production of benzidine continued to rise, and the working conditions were very poor. The workers’ reports of acute cystitis or hematuria were frequently reported. Ten years after the Second World War, cases of bladder cancer gradually increased. In 1948, occupational bladder cancer started to attract the attention of the community as a health issue for industrial workers. Japan’s Ministry of Trade and Industry appointed a committee to investigate the dye industry and began to reform in 1955