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观察正常中国妇女前臂骨量和骨代谢生化指标及其与丹麦妇女的比较。对20~80岁,每岁5名,共305名正常妇女以单能X线吸收法测量非常用侧前壁1/4远端、8mm远端及超远端的骨量和骨密度。骨形成指标为血清骨钙素(OC)及碱性磷酸酶(ALP),骨吸收指标为空腹晨两小时尿I型胶原降解物/肌酐(Type1/Cr)和钙/肌酐(Ca/Cr)。结果:绝经后比绝经前骨量明显减少,1/4远端减少15%,8mm远端为25%,超远端为35%。50岁时我国妇女骨量与丹麦相似,但50岁后,我国妇女骨加速丢失的速度似较快。骨的加速丢失出现在绝经后10~15年内,此后稳定约5~10年。在绝经的最初5年内,含松质骨较多的部位(超远端)骨丢失最多,为16.2%。绝经后骨转换指标明显高于绝经前,与骨量呈负相关。本研究取得了正常中国妇女前臂三个部位的骨量。与丹麦妇女比较表明,东西方妇女骨量与骨代谢规律相似,但有一定差异。
To observe the forearm bone mass and biochemical markers of bone metabolism in normal Chinese women and their comparison with Danish women. A total of 305 normal women aged 20 to 80 years and 5 per woman underwent single-energy X-ray absorptiometry to measure the bone mass and bone mineral density at the distal 1/4, 8 and distal distal extremities. The indexes of bone formation were serum osteocalcin (OC) and alkaline phosphatase (ALP). The bone resorption index was Type1 / Cr and Ca / Cr of urinary type I collagen two hours after fasting, . Results: Compared with premenopausal women, the bone mass decreased significantly after menopause, with a decrease of 15% in 1/4, 25% in 8mm and 35% in distal. At the age of 50, the bone mass in our country is similar to that in Denmark, but after 50 years of age, the speed of loss of bone acceleration in Chinese women seems to be faster. Acceleration of bone loss occurs in 10 to 15 years after menopause, and thereafter stable for about 5 to 10 years. In the first five years of menopause, the site with the highest cancellous bone (super-distal) lost the most bone, which was 16.2%. Postmenopausal bone turnover indicators were significantly higher than before menopause, and bone mass was negatively correlated. The study obtained the bone mass of three parts of normal forearm of Chinese women. Comparison with Danish women shows that the bone mass in eastern and western women is similar to that of bone metabolism, but there are some differences.