论文部分内容阅读
目的：观察硫丙麦角林并用左旋多巴治疗帕金森病（ＰＤ）的疗效与副作用。方法：回顾性分析我院ＰＤ专病门诊中应用本药长期观察的２３例（２例单用硫丙麦角林）。结果：１９／２３例（８３％）用该药有效，维持剂量１５０μｇ～５００μｇ／日。３５％有轻微不良反应，便秘常见。结论：用硫丙麦角林有效率８３％（１７／２１例与左旋多巴类并用），耐受性较好。可与安坦、金刚烷胺、左旋多巴合用并能增加疗效，为临床可选用的ＤＡ受体激动剂之一。
Objective: To observe the efficacy and side effects of pyruvate in the treatment of Parkinson’s disease (PD) with levodopa. Methods: A retrospective analysis of our hospital PD special disease outpatient clinic long-term observation of the application of 23 cases (2 cases of single valproiclin). Results: 19/23 (83%) with the drug effective to maintain the dose of 150μg ~ 500μg / day. 35% have mild adverse reactions, constipation common. CONCLUSIONS: 83% of valproiclin was effective (17/21 with levodopa combined) and was well tolerated. With Antan, amantadine, levodopa combined and can increase the efficacy of clinically available as one of the DA receptor agonists.