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目的:研究小儿肺热咳喘颗粒的急性毒性和长期毒性。方法:急性毒性用LD50法;长期毒性用90d饲喂实验,期间进行一般性观察,末期进行血常规、生化、脏器指数等观察分析。结果:急性毒性实验未见小鼠明显中毒症状,长期毒性表明其对大鼠未引起蓄积性和延迟性毒性。结论:小儿肺热咳喘颗粒无明显急性毒性和长期毒性,临床可安全应用。
Objective: To study the acute toxicity and long-term toxicity of Hyperactivity Kechuan Granule in children. Methods: Acute toxicity was determined by LD50 method. The long-term toxicity was tested by feeding for 90 days. The general observation was performed during the period. The observation of blood routine, biochemistry and organ index were performed at the end of the experiment. Results: Acute toxicity test showed no obvious symptoms of mice, long-term toxicity showed that it did not cause accumulation of rats and delayed toxicity. Conclusion: Hyperactivity cough particles in children no obvious acute toxicity and long-term toxicity, clinical safe application.