Background There remains controversy about whether Brugada syndrome (BS) has structural heart changes. We occasionally noted that a patient with BS had a quite unusual regional wall motion abnormality at the basal segment of the interventricular septum (IVS) during echocardiographic examination. The unexpected finding promoted us to reexamine our patients with BS by echocardiographic interrogation in the present study.Methods Patients with BS (n=11), patients with complete right bundle branch block (RBBB) (n=11), and control subjects(n=11) were enrolled in this study. Two-dimensional echocardiography (2DE) was performed to obtain parastal left ventricular long axis view on which M-mode scanning line was adjusted to be perpendicular to the basal segment of IVS for delineation of the segmental motion curve, with a simultaneously electrocardiographic tracing.Results 2DE revealed a rapid swing motion shifting toward the right ventricle of the IVS basal segment at early systole in 73% (8/11) patients with BS, which was further confirmed on the M-mode curve evidenced by an early systolic notch toward the right ventricle. The position of the notch corresponded to C-point on the mitral motion curve, lasting for (53±5)ms. There were no similar changes both in patients with RBBB and in the control subjects.Conclusion IVS basal motion abnormalities at early-systolic phase may be the novel finding of BS.