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目的 探讨平阳霉素对颊囊癌金黄地鼠肺组织的毒副作用。方法 将 75只金黄地鼠用 5 %DM BA涂擦颊囊诱发颊囊癌后分别用 0 .2mg/kg、0 .4mg/kg和 0 .5mg/kg三种剂量的平阳霉素行腹腔注射 ;对照组每日灌服消炎痛拮抗。结果 随平阳霉素用量的增加 ,金黄地鼠肺炎样变及肺纤维化呈上升趋势 ;消炎痛具有良好的拮抗作用 ,可对抗平阳霉素的肺毒性。结论 平阳霉素用量较大时 (超过 0 .4mg/kg)可出现肺炎样变及肺纤维化 ,如果同时使用消炎痛 ,则可有效地抑制肺纤维化的发生。
Objective To investigate the toxic effects of pingyangmycin on the lung tissue of golden hamster in cheek pouch cancer. Methods 75 golden hamsters were treated with 5% DM BA and the buccal pouch was induced by buccal pouch. After intraperitoneal injection of pingyangmycin at doses of 0.2 mg / kg, 0.4 mg / kg and 0.5 mg / kg respectively, The control group was given indomethacin antagonist daily. Results With the increase of the amount of pingyangmycin, the incidence of pneumonia and pulmonary fibrosis in hamster showed an upward trend. Indomethacin had a good antagonistic effect and could resist the pulmonary toxicity of pingyangmycin. Conclusions When the amount of Pingyangmycin is large (more than 0.4mg / kg), pneumonia and pulmonary fibrosis may occur. If indomethacin is used simultaneously, the occurrence of pulmonary fibrosis can be effectively suppressed.