【摘 要】
：
Atropisomeric anilides are one of important C—N axially chiral compounds.Compared with the N-terminal functionalization to pre-pare such compounds,C-terminal functionalization strategies have been rarely reported.We describe herein an efficient synthesis
【机 构】
：
Department of Chemistry,Fudan University,2005 Songhu Road,Shanghai 200438,China
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Atropisomeric anilides are one of important C—N axially chiral compounds.Compared with the N-terminal functionalization to pre-pare such compounds,C-terminal functionalization strategies have been rarely reported.We describe herein an efficient synthesis of axially chiral anilides enabled by Pd-catalyzed desymmetric Sonogashira cross-coupling reactions with the use of a newly identified Ming-Phos.Moderate to high yields with high enantioselectivities(up to 98％ee)were obtained.
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