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山羊(34只)冠状动脉分枝结扎造成心肌缺血。结扎后遇到的重要问题是心律不齐,可发展到心室纤颤而死亡。采用利多卡因为主的综合预防措施来防止心律不齐,可以减少其死亡率。麻醉剂异戊巴比妥也能减少心律不齐的发生率。异戊巴比妥高剂量组(n=14,41.6±16.5毫升)的利多卡因用量为646.7±220.8克,而低剂量组(n=10,16.5±6.5毫升)的利多卡因用量为1207.5±542.4克。本文采用S—T段和T波的综合幅度来反映心肌缺血的病理状态,并对其意义进行了讨论。胸前心电标测的这种综合波之和,在结扎后三小时的数值与24小时后心肌坏死区的重量有高度的相关性(γ=0.7227)。这种综合波之和,24小时的低于三小时的。血流动力学的变化主要是结扎后左室舒张末期压升高,其他指标的变化可用代偿性反应来解释。
Goats (34) Ligation of the coronary arteries led to myocardial ischemia. An important problem encountered after ligation is arrhythmia, can develop to ventricular fibrillation and death. The use of lidocaine as the primary integrated prophylaxis to prevent arrhythmia can reduce its mortality. Anesthetic Amobarbital can also reduce the incidence of arrhythmia. The amount of lidocaine used in the high-dose amobarbital (n = 14, 41.6 ± 16.5 ml) group was 646.7 ± 220.8 g compared with 1207.5 for the low-dose group (n = 10, 16.5 ± 6.5 ml) ± 542.4 grams. In this paper, the comprehensive amplitude of S-T segment and T-wave is used to reflect the pathological state of myocardial ischemia, and its significance is discussed. The sum of this combined wave of chest ECG showed that there was a high degree of correlation between the three hours after ligation and the weight of the area of myocardial necrosis 24 hours later (γ = 0.7227). The sum of this composite wave, less than three hours in 24 hours. Hemodynamic changes mainly after left ventricular end-diastolic pressure increased, changes in other indicators available compensatory response to explain.