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目的探讨糖尿病患者的血液流变学的改变及其与各种慢性并发症的关系。方法将糖尿病患者分为慢性并发症组及无慢性并发症组，并设立正常对照组，分别进血液流变学测定。慢性并发症组多数病人采用川芎嗪治疗，并于治疗前后检测有关血液流变学指标。结果糖尿病患者血液流变学指标多明显异常，以全血粘度、纤维蛋白原含量升高最为明显，其中慢性并发症组的各项指标又显著高于无并发症组。川芎嗪治疗可明显改善患者的血液流变学异常。结论糖尿病患者血液流变学指标显著异常，川芎嗪可缓解糖尿病慢性并发症并显著改善血液流变学指标。
Objective To investigate the changes of hemorheology in diabetic patients and its relationship with various chronic complications. Methods Diabetic patients were divided into chronic complications group and non-chronic complications group, and a normal control group was established, respectively, into the blood rheology measurement. Most patients in the chronic complication group were treated with ligustrazine, and hemorheological indexes were detected before and after treatment. Results The indexes of hemorheology in diabetic patients were obviously abnormal. The whole blood viscosity and the content of fibrinogen were the most obvious. The indexes of chronic complications group were significantly higher than those without complications. Tetramethylpyrazine treatment can significantly improve the patient’s hemorheology abnormalities. Conclusion The indexes of hemorheology in diabetic patients are significantly abnormal. Ligustrazine can relieve the chronic complications of diabetes and significantly improve the indexes of hemorheology.