1984年,Nakamura T等[1]从部分肝切除大鼠的血清中分离到一种能刺激原代培养的肝细胞生长和合成的肝源性因子,并首次命名为肝细胞生长因子(Hepatocyte Grouth Factor,HGF)。此后,许多国家对HGF进行了一系列深入研究,认为是一类能促进人类及动物肝细胞再生的具有生物活性的小分 In 1984, Nakamura T et al [1] isolated from a partial hepatectomy rat serum can stimulate the primary culture of liver cell growth and synthesis of liver-derived factor, and for the first time named hepatocyte growth factor (Hepatocyte Grouth Factor, HGF). Since then, many countries conducted a series of in-depth studies of HGF as a class of bioactive small molecules that promote the regeneration of human and animal hepatocytes