论文部分内容阅读
荧光原位杂交(FISH)是一种具有高度灵敏性和特异性的染色体和基因分析技术,目前广泛用于产前诊断各种染色体异常,不仅可以用于羊水或绒毛细胞来筛查非整倍体同时可以用于母亲外周血分离胎儿有核红细胞及宫颈冲洗收集滋养细胞等细胞数少、不适合常规染色体分析的染色体异常的检测。FISH技术还发展到植入前遗传学诊断对单个细胞进行染色体检查选择适宜的胚胎植入宫腔从而避免患儿的出生。
Fluorescence in situ hybridization (FISH) is a highly sensitive and specific chromosomal and genetic analysis technique that is currently widely used in prenatal diagnosis of various chromosomal abnormalities not only for amniotic fluid or villus cells to screen for aneuploidy Body at the same time can be used for separation of the mother’s peripheral blood fetal nucleated red blood cells and cervical washing trophoblast collection and other small number of cells is not suitable for routine chromosomal analysis of chromosomal abnormalities detected. FISH technology has also been developed to preimplantation genetic diagnosis of chromosomes on a single cell selection suitable embryo implantation in the uterine cavity to avoid the birth of children.