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目的探讨复发性阿弗他溃疡(RAU)患者凝血、抗凝及纤溶指标的变化及临床意义。方法选取RAU患者58例,分为轻型阿弗他溃疡(MiAU)组、重型阿弗他溃疡(MjAU)组及疱疹样阿弗他溃疡(HU)组,以50例健康成人为对照组,采用ACL-200型全自动凝血分析仪、酶联免疫吸附(ELISA)法检测血浆凝血因子VⅢ活性(FVⅢ:C)、蛋白C抗原(PC:Ag)、总蛋白S抗原(TPS:Ag)、组织型纤溶酶原激活物抗原(t-PA:Ag)、纤溶酶原激活剂抑制物-1抗原(PAI-1:Ag)、D-二聚体(D-Dimer)含量。结果 RAU患者PC:Ag、TPS:Ag、PAI-1:Ag、D-Dimer含量均高于对照组(P均<0.01),t-PA:Ag明显低于对照组(P<0.01)。MjAU组PC:Ag低于MiAU组(P<0.05);MiAU组FVⅢ:C显著高于对照组(P<0.01),而MjAU组FVⅢ:C虽高于对照组,但差异无统计学意义(P>0.05)。结论 RAU患者体内存在凝血、抗凝及纤溶系统异常,而FVⅢ:C、PC:Ag水平与疾病的严重程度有关。
Objective To investigate the changes and clinical significance of coagulation, anticoagulation and fibrinolysis in patients with recurrent aphthous ulcer (RAU). Methods Fifty-eight RAU patients were selected and divided into three groups: the mild ulcerative colitis group (MAU), the severe hypothermia group (MUUA) and the group of herpes simplex alveolar ulcer (HU). Fifty healthy adults served as the control group. ACL-200 automatic coagulation analyzer and enzyme-linked immunosorbent assay (ELISA) were used to detect plasma coagulation factor VⅢ activity (FVⅢ: C), protein C antigen (PC: Ag), total protein S antigen (T-PA: Ag), plasminogen activator inhibitor-1 antigen (PAI-1: Ag) and D-dimer were measured. Results The levels of PC: Ag, TPS: Ag, PAI-1: Ag and D-Dimer in RAU patients were significantly higher than those in control group (all P <0.01). In MjAU group, the ratio of PC: Ag was lower than that in MiAU group (P <0.05); FVIII: C in MiAU group was significantly higher than that in control group (P <0.01), while MjAU group was higher than control group P> 0.05). Conclusion Coagulation, anticoagulation and fibrinolytic system are abnormal in RAU patients. The levels of FVIII: C and PC: Ag are related to the severity of the disease.