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于米非司酮多次给药后，对SD大鼠子代的生长发育、生殖毒性、遗传毒性以及形态变化等进行了检测。结果表明，用药组大鼠于妊娠第7～9天先用抗早孕剂量的米非司酮4mg·ks~（－1）·d~（－1）共3d，终止第1次妊娠，隔2周后重复上述过程，终止第2次妊娠，于第3次合笼前给米非司酮ling·kg~（－1）·d~（-1）共14d，然后与♂鼠合宠，确定妊娠的当天，米非司酮减量至0．5mg·kg~（－1）·d~（－1）共15d，至孕20d，半数鼠解剖取材，另半数鼠产仔，观察各项指标。本实验条件下，米非司酮多次用药后对大鼠胚胎的肝脏淋巴细胞染色体畸交率与微核率，对幼鼠骨髓细胞姐妹染色单体互换率均未见明显的遗传学影响，产出的幼鼠生长发育良好，所测各项有关生殖毒性及形态变化的指标与对照鼠无明显差异。
After multiple doses of mifepristone, the growth and development, reproductive toxicity, genotoxicity and morphological changes of SD rats were detected. The results showed that the first pregnancy was terminated on the 7th to the 9th day of gestation in pregnant women with mifepristone 4mg · ks -1 · d -1 for 3 days, Repeat the process weeks later to terminate the second pregnancy, mifepristone ling · kg ~ (-1) · d ~ (-1) for 14 days before the third cessation, On the day of pregnancy, mifepristone was reduced to 0.5 mg · kg -1 d -1 for 15 days. Twenty days after the pregnancy, half of the mice were sacrificed and the other half were sacrificed. The indexes . Under the experimental conditions, there was no significant genetic effect on the chromosome aberration rate and micronucleus rate of liver lymphocytes in rat embryos and the sister chromatid exchange rate of immature bone marrow cells after multiple doses of mifepristone , The output of young rats grow well, the measured indicators of reproductive toxicity and morphological changes and control mice no significant difference.