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目的比较黄连解毒汤中栀子苷在正常和脑缺血大鼠体内的动力学过程。方法正常大鼠及脑缺血大鼠ig黄连解毒汤后不同时间采血,用HPLC法测定栀子苷的血药浓度,3P87软件拟合药动学参数。结果脑缺血及正常大鼠栀子苷药动学符合一室模型。脑缺血及正常状态下大鼠ig黄连解毒汤后,栀子苷在脑缺血及正常状态下体内的AUC分别为(15.819±5.228)、(11.395±3.111)μg.h.mL-1,t1/2ke分别为(4.704±1.850)、(3.695±1.595)h,Cmax分别为(2.135±0.202)、(1.677±0.621)μg/mL。结论栀子苷在脑缺血状态下的血药浓度及吸收效果优于正常状态,在体内停留的时间较长,消除较慢,反映了黄连解毒汤临床对症治疗脑缺血疾病的合理性,体现了方证对应的思想。
Objective To compare the kinetic process of geniposide in Huanglian Jiedu Decoction in normal and cerebral ischemia rats. Methods Normal rats and cerebral ischemia rats were treated with ig Huanglian Jiedu Decoction at different times, the blood concentration of geniposide was determined by HPLC, and the pharmacokinetic parameters were fitted by 3P87 software. Results The cerebral ischemia and normal rats geniposide pharmacokinetic fit a one-compartment model. After cerebral ischemia and normal rats ig Huanglian Jiedu Decoction, the AUC of geniposide in cerebral ischemia and normal state were (15.819 ± 5.228), (11.395 ± 3.111) μg.h.mL-1, t1 / 2ke were (4.704 ± 1.850) and (3.695 ± 1.595) h, respectively, and the Cmax were (2.135 ± 0.202) and (1.677 ± 0.621) μg / mL, respectively. Conclusion Geniposide plasma concentration and absorption better than the normal state in the state of cerebral ischemia, stay in the body longer, to eliminate slower, reflecting the Huanglian Jiedu Decoction clinical symptomatic treatment of cerebral ischemia is reasonable, Embodies the square card corresponding to the idea.