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[目的]观察上海某专科医院女性肺癌住院患者的临床特征及生存情况。[方法]以2000年1月至2001年12月期间于上海市胸科医院诊治的全部沪籍女性肺癌住院病人作为研究对象,通过病历回顾收集相关资料,并跟踪随访至2009年3月30日。采用描述性分析和寿命表法进行生存分析。[结果]346名病例的平均患病年龄为(59.0±10.4)岁,其中为19例(5.5%)吸烟者;34例(9.8%)为有肿瘤家族史者;腺癌比例最高,为253例(80.8%),腺鳞型、鳞型其次。从病程分期看,65%的病例首次诊断时都已是Ⅲ、Ⅳ期;单纯手术治疗110例、手术联合放化疗5例、手术加化疗76例、单纯化疗92例、放化疗29例及未治疗患者34例。生存分析结果显示,Ⅰa、Ⅰb、Ⅱa、Ⅱb、Ⅲa、Ⅲb、Ⅳ期的中位生存期分别是9.0、9.0、9.0、2.2、1.9、1.2、0.9年(P<0.01),鳞、腺、腺鳞及小细胞型的中位生存期分别是7.0、2.0、1.7、1.2年(P<0.01)。单纯手术、手术联合放化疗、手术加化疗、单纯化疗、放化疗及未治疗患者的中位生存期分别是8.3、6.3、2.9、1.0、0.9、0.7年。[结论]女性肺癌以腺癌为主,不同病理类型、临床分期及不同治疗方式的女性肺癌患者的生存期明显不同。要加强人群定期体检的意识,提高肺癌高危人群定期体检率,早期诊断,提高组织病理学的确诊率,争取手术治疗时机,以改善预后。
[Objective] To observe the clinical characteristics and survival of female lung cancer hospitalized in a special hospital in Shanghai. [Methods] All the patients with lung cancer admitted to Shanghai Chest Hospital from January 2000 to December 2001 were enrolled in this study. The relevant data were collected through the review of medical records and followed up until March 30, 2009 . Survival analysis using descriptive analysis and life table method. [Results] The average age at onset of 346 cases was (59.0 ± 10.4) years, of which 19 (5.5%) smokers, 34 (9.8%) had a family history of cancer, and the highest proportion of adenocarcinoma was 253 Cases (80.8%), adenosquamous, squamous type followed. Seen from the stage of disease, 65% of the cases were the first diagnosis of Ⅲ, Ⅳ; simple surgery in 110 cases, surgery combined with radiotherapy and chemotherapy in 5 cases, surgery plus chemotherapy in 76 cases, chemotherapy alone in 92 cases, 29 cases of radiotherapy and chemotherapy Treatment of 34 patients. The results of survival analysis showed that the median survival time of Ⅰa, Ⅰb, Ⅱa, Ⅱb, Ⅲa, Ⅲb and Ⅳ were 9.0,0.9,0.2,0.2,1.9,1.2,0.9 (P <0.01) The median survival of adenosquamous and small cell types was 7.0, 2.0, 1.7, 1.2 years (P <0.01). The median survival time of simple surgery, operation combined with radiotherapy and chemotherapy, operation plus chemotherapy, chemotherapy alone, radiotherapy and chemotherapy and untreated patients were 8.3, 6.3, 2.9, 1.0, 0.9, 0.7 years respectively. [Conclusion] The main lung cancer in women is adenocarcinoma, and the survival of women with different pathological types, clinical stage and different treatment methods is significantly different. To strengthen the awareness of regular physical examination of the population to improve the regular check-up rate of high-risk groups of lung cancer, early diagnosis and improve the diagnosis rate of histopathology, strive for the timing of surgery to improve the prognosis.