一 绪言 淀粉样变症是淀粉样变在全身细胞间、组织间隙沉积的疾病。实验动物中本病的自发率较高。已明确小鼠的发病情况与品系和年龄有关。 据报导,地鼠的淀粉样变症随年龄增长而发生,多发于肝、脾、肾和肾上腺。我们发现从Charles River公司引进的Lakeview系地鼠繁殖群、15月龄以上的雌鼠出现精神不佳,消瘦及皮下浮肿等异常症状。病理学检查,发现全身各脏器,特别是肾脏,明显可见淀粉样变沉积。有关临床症状及病理变化,概要报告如下: An Introduction Amyloidosis is amyloidosis in the whole body cells, interstitial deposition of disease. The high incidence of spontaneous disease in experimental animals. It is clear that the incidence of mice and strains and age-related. It has been reported that the amyloidosis of hamsters occurs with age and occurs in the liver, spleen, kidney and adrenal gland. We found that Lakeview, a gopher breeding herd introduced from Charles River, showed abnormal symptoms such as poor health, weight loss and subcutaneous edema in females aged 15 months and older. Pathological examination found that the body organs, especially the kidneys, obviously visible amyloid deposition. For clinical symptoms and pathological changes, a summary report is as follows: