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目的探讨HLA-DRB1*14和*15等位基因与肝癌发生的相关性。方法以40例原发性肝癌患者作为病例组,以135例健康人作为对照组,应用PCR-SSP方法对研究对象外周血的HLA-DRB1等位基因进行检测,分析其表达与原发性肝癌的相关性。结果 HLA-DRB1*14在病例组中的分布频率较对照组显著增高(χ2=9.925,P=0.002,OR=3.450,95%CI:1.555～7.655),HLA-DRB1*15在病例组和对照组中的分布频率的差异无统计学意义(χ2=1.260,P=0.262,OR=1.538,95%CI:0.723～3.274)。结论 HLA-DRB1*14可能是原发性肝癌的易感基因,HLA-DRB1*15可能与原发性肝癌的发生无明显关系。
Objective To investigate the association between HLA-DRB1 * 14 and * 15 alleles and the occurrence of hepatocellular carcinoma. Methods 40 cases of primary liver cancer patients as the case group and 135 healthy people as the control group, PCR-SSP method was used to detect HLA-DRB1 alleles in the peripheral blood of the study subjects, and its expression was compared with that of primary liver cancer Relevance. Results The distribution frequency of HLA-DRB1 * 14 in the case group was significantly higher than that in the control group (χ2 = 9.925, P = 0.002, OR = 3.450, 95% CI: 1.555-7.655) There was no significant difference in the frequency of distribution between groups (χ2 = 1.260, P = 0.262, OR = 1.538, 95% CI: 0.723-3.274). Conclusion HLA-DRB1 * 14 may be a predisposing gene for primary liver cancer. HLA-DRB1 * 15 may not be associated with the occurrence of primary liver cancer.