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目的:研究大黄、虫对药组合对雌、孕激素负荷大鼠子宫肌瘤模型血液流变学影响。方法:将70只雌性SD大鼠随机分为7组:正常对照组、模型组、大黄虫小剂量组、大黄虫中剂量组、大黄虫大剂量组、大黄虫丸组、桂枝茯苓胶囊组,采用雌孕激素负荷法建立子宫肌瘤模型,血流变仪检测血液流变学指标。结果:大黄、虫能明显改善血液流变学各项指标。结论:大黄、虫对药能显著改善子宫肌瘤模型大鼠“瘀血内阻”的病理变化。
Objective: To study the effect of rhubarb and aphid on the hemorheology of uterine fibroid models in female and progesterone-loaded rats. METHODS: Seventy female SD rats were randomly divided into 7 groups: normal control group, model group, small dose of rhubarb, middle dose of rhubarb aphid, large dose of rhubarb aphids, rhubarb, astragalus, cassia twig. In the capsule group, the uterine fibroid model was established by the estrogen and progesterone loading method, and the blood rheology instrument was used to detect the hemorheological parameters. Results: Rhubarb and aphids can significantly improve the indexes of hemorheology. Conclusion: Rhubarb and aphid can significantly improve the pathological changes of “blood stasis resistance” in rats with uterine fibroids.