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目的:探讨胸椎旁神经阻滞联合静脉全身麻醉在腔镜食管癌根治术中的应用效果。方法:抽取2018年1月至2019年1月于郑州大学附属肿瘤医院接受治疗的食管癌患者80例，采用随机数字表法分为联合组和对照组，每组40例。所有患者接受腔镜食管癌根治术，对照组给予静脉全身麻醉，联合组在此基础上实施胸椎旁神经阻滞。比较两组患者手术一般情况、免疫功能和视觉模拟评分法(VAS)评分、匹兹堡睡眠质量指数表(PSQI)评分。结果:联合组平均动脉压、心率小于对照组，舒芬太尼用量低于对照组(n P0.05)；术前，两组CD3n ＋、CD4n ＋及自然杀伤细胞(NK)细胞水平比较差异未见统计学意义(n P>0.05)，术后，两组CD3n ＋、CD4n ＋及NK细胞水平较本组术前下降，联合组CD3n ＋、CD4n ＋及NK水平高于对照组(n P0.05), and were decreased in both groups after operation, and were higher in combination group than in control group (n P<0.05). Postoperative scores of VAS and PSQI in combination group were lower than those in control group (n P<0.05).n Conclusions:The application of thoracic paravertebral block combined with venous general anesthesia in radical resection of esophageal carcinoma can maintain stable the arterial prssure and heart rate of patients durong operation, protect the immune function of patients, effectively relieve postoperative pain, promote sleep.