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药物在体内的各种平均时间是药物动力学研究的重要指标。通过一种新的矩阵运算定义了导出矩阵,从而解决了药物速率常数转化为转移概率的问题,推导了药物在体内动态过程的吸收马尔可夫链典范式矩阵和基本矩阵,从基本矩阵可得药物在体内各部位吸收、转运和消除的平均时间的计算公式。
The mean time of drug in the body is an important indicator of pharmacokinetic studies. The derivation matrix is defined by a new matrix operation to solve the problem that the drug rate constant is transformed into the transition probability. The absorption matrix of matrix and basic matrix of absorption Markov chain in the dynamic process of the drug are derived. From the basic matrix, Drugs in various parts of the body absorption, transport and elimination of the average time formula.