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目的 观察A型肉毒毒素治疗偏侧面肌痉挛的临床疗效。方法 采用A型肉毒毒素多点局部注射偏侧面肌痉挛患者35例, 6个月后观察疗效,其中复发者1个月后再次给予治疗,最多注射治疗3次。并使用Cohen和Albert量表进行评估。结果 6个月后症状完全好转30例,占85.71%;明显改善4例,占11.42%;部分改善1例,占2.85%。疗效平均持续约3~6 个月,复发者重复注射仍有效,出现局部面部肿胀3例,眼睑闭合不全2例,面肌无力、眼睑下垂各为一例, 但是未经过任何处置均在1周内恢复。结论 局部注射A型肉毒毒素确为一种安全有效、简便易行的治疗偏侧面肌痉挛的方法。
Objective To observe the clinical efficacy of Botulinum toxin A in the treatment of hemifacial spasm. Methods A total of 35 patients with partial hemifacial spasm were injected with botulinum toxin A, and the curative effect was observed after 6 months. The recurrence was given again after 1 month and the treatment was given up to 3 times. And assessed using the Cohen and Albert scales. Results After six months, the symptoms improved completely in 30 cases (85.71%), significantly improved in 4 cases (11.42%), partially improved in 1 case (2.85%). The curative effect lasted for an average of 3 to 6 months. Repeated injections were still effective in relapsed patients. There were 3 cases of local facial swelling, 2 cases of eyelid insufficiency, one case of facial weakness and eyelid ptosis, but within 1 week without any treatment restore. Conclusion Local injection of botulinum toxin type A is indeed a safe, effective and simple method for the treatment of hemifacial spasm.