目的分析国家免费孕前优生项目高风险人群检查结果及高风险因素的分布情况,为项目科学发展提供依据。方法对济南市历城区近5年来孕前优生检查的高风险人群检查结果进行分析。结果吸烟(含被动吸烟)、肝功异常等在男性中发生率较高,女性甲状腺疾病的发病率较高。在男女共查的项目中,男性比女性高风险因素发生率高,差异有统计学意义(χ2=23.85,P<0.05)。结论详细的病史采集和正确的实验室检查是保证风险评估质量的基础,对高风险人群的指导要全面;要增加男性查体率。 Objective To analyze the distribution of high risk population and high risk population in prenatal prenatal care programs in the country and provide basis for the scientific development of the project. Methods The results of the examination of high risk groups of prenatal checkup in the past five years in Licheng District of Jinan City were analyzed. Results Smoking (including passive smoking), liver dysfunction and other higher incidence in men, women with a higher incidence of thyroid disease. Among male and female co-enrolled projects, men had higher incidence of high-risk factors than women, the difference was statistically significant (χ2 = 23.85, P <0.05). Conclusions Detailed medical history collection and correct laboratory examination are the basis for ensuring the quality of risk assessment. The guidelines for high-risk groups should be comprehensive and the rate of male physical examination should be increased.