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目的通过不同程度肾间质纤维化(RIF)肾穿刺病理检查(RBP)与螺旋CT薄层动态增强扫描(SCTDCS)对照,探讨RIF病理与螺旋CT诊断指标之间的相关性。方法收集经RBP检查证实的正常及轻中重度RIF患者112例,肾活检病理组织行光镜及免疫组化检查,行肾脏SCTDCS作出影像诊断。结果中、重度RIF组肾皮/髓质厚度比、CT值及肾体积改变与对照组相比,差异均具有统计学意义(P<0.05),与轻度组比较,差异无统计学意义(P>0.05);SCTDCS诊断RIF的敏感性为70.7%,准确性为78.6%,特异性为86.7%。结论SCTDCS通过综合判断肾脏相关指标其诊断RIF的敏感性、特异性、准确性较高,可为临床诊断RIF提供影像学依据。
Objective To investigate the correlation between RIF pathology and the diagnostic value of spiral CT by different degrees of renal interstitial fibrosis (RIF) renal biopsy (RBP) and spiral CT thin layer dynamic contrast-enhanced scanning (SCTDCS). Methods One hundred and twelve patients with normal and mild to moderate RIF confirmed by RBP were collected. Pathological examination of renal biopsy was performed by light microscope and immunohistochemistry. Imaging diagnosis was performed with renal SCTDCS. Results In the severe RIF group, there were significant differences in the ratio of renal crush / medullary thickness, CT value and renal volume compared with the control group (P <0.05), but there was no significant difference between the two groups P> 0.05). The sensitivity of SCTDCS in the diagnosis of RIF was 70.7%, the accuracy was 78.6% and the specificity was 86.7%. Conclusion The sensitivity, specificity and accuracy of SCTDCS in diagnosing RIF by comprehensively judging renal related indexes may provide imaging evidence for clinical diagnosis of RIF.