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目的研究阿克他利大鼠在体肠吸收动力学特征。方法采用大鼠在体单向灌流法进行肠吸收实验,以吸收速率常数(ka)和表观吸收系数(Papp)为指标,从灌流速度、药物浓度和吸收部位3个方面对阿克他利肠吸收动力学特征进行考察。结果不同灌流速度下的ka和Papp有极其显著性差异(P<0.01);药物浓度在一定范围内对ka和Papp无显著性影响(P>0.05);小肠各段(十二指肠、空肠、回肠)的ka和Papp无显著性差异(P>0.05);小肠与结肠的ka存在极其显著性差异(P<0.01),Papp存在显著性差异(P<0.05)。结论阿克他利在整个肠道吸收良好,但吸收窗主要在小肠,在结肠段的吸收相对较差。
Objective To study the kinetics of absorption of acetochi in the intestine of rats. Methods The intestine absorption test was performed in rats by one-way perfusion in vivo. The absorption rate constant (ka) and apparent absorption coefficient (Papp) were used as indexes to evaluate the effects of acytoin on the perfusion rate, drug concentration and absorption site Intestinal absorption kinetics characteristics were investigated. Results There was a significant difference between ka and Papp under different perfusion rates (P <0.01). There was no significant effect of drug concentration on ka and Papp within a certain range (P> 0.05) (P> 0.05). There was significant difference between Ka and Papp in small intestine and colon (P <0.01) and Papp (P <0.05). Conclusions Actidali absorbed well throughout the intestine, but the absorption window was predominantly in the small intestine with relatively poor absorption in the colon segment.