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目的 :探讨血清肿瘤特异性生长因子 (TSGF)测定在妇科肿瘤的诊断和对卵巢恶性肿瘤患者疗效观察中的意义。方法 :检测未经治疗的 6 4例卵巢恶性肿瘤、 34例子宫内膜癌、 5 1例子宫颈癌、 15例子宫绒癌、 47例卵巢良性肿瘤、 5 5例子宫肌瘤患者 ,5 7例正常女性血清 TSGF含量 ,同时定期测定 5 1例治疗后卵巢恶性肿瘤血清 TSGF含量。结果 :卵巢恶性肿瘤、子宫内膜癌、子宫颈癌患者血清 TSGF值及阳性率明显高于子宫绒癌、妇科良性肿癌者及正常对照组 ,卵巢恶性肿瘤组明显高于卵巢良性肿瘤组。治疗中卵巢恶性肿瘤完全缓解者血清 TSGF值逐渐下降 ,部分缓解者先下降后上升 ,病情恶化者在较高水平上持续上升。结论 :血清 TSGF测定可作为妇科肿瘤诊断中的重要辅助指标 ,同时在观察卵巢恶性肿瘤患者的病情和疗效中有重要意义。
Objective: To investigate the significance of serum tumor specific growth factor (TSGF) in the diagnosis of gynecological tumors and the observation of the therapeutic effect on patients with ovarian cancer. METHODS: Totally 64 untreated ovarian malignancies, 34 endometrial cancers, 51 cervical cancer, 15 uterine tumors, 47 benign ovarian tumors and 55 uterine fibroids were examined. Fifty-seven Serum TSGF levels of normal women, while regular determination of 51 cases of ovarian cancer serum TSGF levels. Results: Serum TSGF levels and positive rates in patients with ovarian cancer, endometrial cancer and cervical cancer were significantly higher than those in uterine choriocarcinoma, gynecologic benign tumor and normal control group, and were significantly higher in ovarian cancer group than in benign ovarian tumor group. Serum TSGF values of patients with complete remission of ovarian malignancies gradually decreased after treatment, and those with partial remission first decreased and then increased, while those with worsening condition continued to rise at a higher level. Conclusion: Serum TSGF can be used as an important auxiliary indicator in the diagnosis of gynecological tumors, and it is of great significance in the observation of the disease and the curative effect of patients with ovarian cancer.