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目的研究制川乌配伍甘草对制川乌中多种单酯型生物碱煎出量的影响,探索其变化规律,以指导制川乌与甘草的合理配伍。方法 HPLC法测定制川乌与甘草不同比例配伍时煎出液中单酯型生物碱的总量,并通过对比,分析不同配比对煎出量的影响。结果随着甘草配伍量的增加,煎煮液中单酯型生物碱总量逐渐降低,每种单酯型生物碱煎出量趋于单煎液煎出量的40%。结论甘草配伍制川乌时,甘草的使用量应是制川乌的一半以上,既可以保证煎出液中单酯型生物碱总量稳定可控,又可以防止制川乌毒性过大造成使用危险。
Objective To study the effects of Radix Aconiti preparata on licorice extract of Radix Aconiti Preparatum and explore its variation to guide the rational compatibility of Radix Aconitum and Radix Glycyrrhizae. Methods The total amount of monoester alkaloids in the decoction of Radix Aconiti Kusnezoffii and Radix Glycyrrhizae with different proportions was determined by HPLC, and the effects of different proportions on the amount of decoction were analyzed. Results With the increase of the compatibility of licorice, the total amount of monoester alkaloids in the decoction gradually decreased, and the decocted amount of each monoester alkaloid tended to be 40% of the decocted amount of decoction. Conclusion Glycyrrhiza uralensis compatibility, the use of licorice should be more than half of Radix Aconiti Preparata, not only can guarantee the stability of the total amount of monoester alkaloids in the decoction liquid is stable and controllable, but also can prevent the use of Danger.