细菌性脑膜炎(BM)确切的发病机制尚不完全清楚,氧化应激所致神经损伤是BM的病理机制之一。大量研究证实氧化应激可以引起大脑皮层神经元的坏死和海马神经元的凋亡,而这些神经损伤均与脑膜炎后神经系统后遗症密切相关。研究发现,外源性给予维生素类、化学合成类、酶类等抗氧化剂对细菌性脑膜炎的神经损伤有一定的保护作用。 The exact pathogenesis of bacterial meningitis (BM) is not fully understood. Oxidative stress-induced nerve injury is one of the pathological mechanisms of BM. Numerous studies have confirmed that oxidative stress can cause neuronal necrosis of the cerebral cortex and apoptosis of hippocampal neurons, and these nerve injuries are closely related to post-meningitis neurological sequelae. The study found that exogenous administration of vitamins, chemical synthesis class, enzymes and other antioxidants on the bacterial meningitis nerve injury have a protective effect.