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目的研究参术胶囊对脾虚胃癌转移鼠动物模型胃癌细胞形态的影响,探讨参术胶囊抗脾虚胃癌转移的作用机理。方法在建立裸鼠脾虚胃癌转移病证结合动物模型基础上,采用HE染色方法研究参术胶囊对脾虚胃癌转移鼠动物模型癌细胞分化的影响。结果参术胶囊对胃癌组织细胞分化有明显调控作用。结论参术胶囊具有改善瘤细胞的异型性,诱导胃癌组织细胞重新分化的作用,这可能是参术胶囊抗脾虚胃癌转移的作用机制之一。
Objective To investigate the effect of Shenzhu Capsule on the morphology of gastric cancer cells in spleen-deficient gastric cancer metastasis rat model, and to explore the mechanism of Shenshu Capsule on anti-spleen deficiency gastric cancer metastasis. Methods Based on the animal model of metastasis of spleen-deficiency gastric cancer in nude mice, HE staining was used to study the effect of Shenshu capsule on the differentiation of cancer cells of spleen-deficient gastric cancer model rats. Results Shenshu Capsule can obviously regulate cell differentiation of gastric cancer. Conclusion Shenshu Capsule can improve the atypicality of tumor cells and induce the redifferentiation of gastric cancer cells. This may be one of the mechanisms of Shenshu Capsule in preventing the metastasis of gastric cancer due to spleen deficiency.