帕金森病(PD)运动症状归因于黑质多巴胺能神经元变性所产生的纹状体多巴胺能缺损。应用SPECT或PET多巴胺运载体结合点成像技术可以证实PD患者纹状体多巴胺能神经末梢的减少。为此,本研究将早期PD患者与对照组的纹状体多巴胺运载体结合点进行对比,以评价[Ⅰ-123]IPT与SPECT是否能成为一种检测早期特别是亚临床疾病的有用工具。 Parkinson’s disease (PD) motor symptoms are due to striatal dopaminergic defects resulting from degeneration of substantia nigra dopaminergic neurons. Depletion of striatal dopaminergic nerve endings in PD patients can be demonstrated using SPECT or PET dopamine transporter binding site imaging. To do this, we compared striatum dopamine transporter binding sites in patients with early-stage PD with those in the control group to evaluate whether [I-123] IPT and SPECT could be a useful tool to detect early and particularly subclinical disease.