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目的 :探讨紫外线 (Ultraviolet)的免疫抑制机制.方法 :体外观察紫外线B(UVB)对豚鼠郎格汉斯细胞 (LC)刺激自体淋巴细胞增殖能力的影响.结果 :UVB以剂量依赖性方式抑制LC刺激自体淋巴细胞增殖能力.低剂量UVB( 2 5J/m2 )没有抑制作用 ,50J/m2 抑制率为 2 2 4%,10 0J/m2 抑制率为 54 5%,2 0 0J/m2 几乎可以完全抑制淋巴细胞增殖反应.结论 :紫外线可以直接抑制LC的功能 ,其免疫抑制机理可能与干扰LC表面分子自体调节有关“,”Objective:To study the immunosuppression mechanism of Ultraviolet (UV) . Methods: In vitro,the auto lymphocyte proliferation test with LC in guinea-pig was investigated . Results: It showes that UVB significantly inhibited LC auto-stimulatory property in dose-dependent way. That enriched LC suspensions exposure to low doses of UVB(25 J/m 2) radiation does not significantly affect their auto-stimulatory capacity , the inhibition ratio of UVB irradiation is 22.4%,50% in dose of 50J/m 2 and 100J/m 2. At 200 J/m 2 it almost completely abrogated the lymphocyte proliferation.Conclusion: UVB can inhibit the function of LC directly. The mechanism of immunosuppression induced by UVB may be proposed that it may interrupt the auto-regulation of surface molecules of LC.