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1976年我们在筛选治疗矽肺药物中,发现汉防己甲素(简称汉甲素)(Tedrandrinc)对大鼠实验性矽肺具有明显的治疗效果,以后又发现汉甲素在大鼠及人体内可以代谢生成汉甲-N-2′-氧化物(简称汉甲—NO)。为了研究汉甲-NO对矽肺的治疗
In 1976, we screened for the treatment of silicosis drugs and found that tetrandrine (Tedrandrinc) has obvious therapeutic effect on rat experimental silicosis, and later found that it can be metabolized in rats and humans N-methyl-N-2’-oxide (Han-NO). In order to study the treatment of silico-N-methyl-NO