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周围淋巴细胞染色体改变作为遗传毒性及其受生活方式影响的指标ＫａｎｅｈｉｓａＭｏｒｉｍｏｔｏｅｔａｌ．一、引言染色体改变系一直观的ＤＮＡ改变，与致癌、致畸与致衰老性密切相关。循环血液中的淋巴细胞是最易获取的人类细胞样本，能反映出环境和职业遗传毒性因子的...
Peripheral lymphocyte chromosome changes as a marker of genotoxicity and its impact on lifestyle Kanehisa Morimoto et al. I. INTRODUCTION Chromosomal alterations are consistent changes in DNA that are closely related to carcinogenesis, teratogenicity and senescence. Circulating blood lymphocytes is the most accessible sample of human cells that can reflect environmental and occupational genotoxicity ...