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目的 检测血清中可溶性细胞黏附分子 1(sICAM 1)含量 ,探讨其在结直肠癌早期诊断中的意义。方法 采用酶联免疫吸附试验法测定 6 0例结直肠癌、2 1例胃癌、17例乳腺癌及 9例正常人血清中sICAM 1的含量。结果 结直肠癌和胃癌血清中sICAM 1较正常人明显增高 (P <0 0 1) ,乳腺癌血清中sICAM 1与正常人比较无显著性差异 (P >0 0 5 ) ,结直肠癌血清中sICAM 1阳性率较胃癌高 (P <0 0 5 ) ,结直肠癌血清中sICAM 1的含量与其病程及病理显著相关。结论 血清中sICAM 1的水平测定可做为结直肠癌的早期诊断标准之一。
Objective To detect the content of soluble cell adhesion molecule 1 (sICAM 1) in sera and explore its significance in the early diagnosis of colorectal cancer. Methods Serum levels of sICAM 1 in 60 cases of colorectal cancer, 21 cases of gastric cancer, 17 cases of breast cancer and 9 cases of normal human were determined by enzyme linked immunosorbent assay (ELISA). Results The serum sICAM 1 in colorectal cancer and gastric cancer was significantly higher than that in normal people (P <0.01). The serum sICAM 1 in breast cancer was no significant difference compared with normal people (P> 0.05) The positive rate of sICAM-1 was significantly higher than that of gastric cancer (P <0.05). The level of sICAM-1 in colorectal cancer serum was significantly correlated with its pathology and pathology. Conclusion Serum sICAM 1 levels can be used as one of the early diagnostic criteria for colorectal cancer.