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目的观察铅对接触噪声工人听力损伤的协同作用及可能机制。方法选择年龄、工龄及接触噪声强度相近的观察组和对照组工人,测定两组工人的单耳单频听阈、血清中超氧化物歧化酶(SOD)活力和丙二醛(MDA)含量,同时测定两组工人血中铅含量,并比较两组数据差异。结果观察组的单耳听阈在4和6 k Hz,明显高于对照组,两者比较,差异有统计学意义(P<0.05);观察组和对照组的血中铅浓度分别为(1.9±0.7)和(0.8±0.2)μmol/L,两者比较,差异有统计学意义(P<0.01);观察组和对照组的血清中SOD含量分别为(67.2±15.3)和(64.7±13.6)U/ml,两者比较,差异无统计学意义(P>0.05);观察组和对照组的血清中MDA含量分别为(7.31±3.36)和(6.53±2.78)μmol/L,两者比较,差异有统计学意义(P<0.05)。结论铅对接触噪声工人听力损伤具有协同作用,自由基损害可能是其机制之一。
Objective To observe the synergistic effect of lead on hearing loss of workers exposed to noise and its possible mechanism. Methods The workers in the observation group and the control group with similar age, length of service, and exposure to noise were selected to measure the mononeurial hearing threshold, the activity of serum superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in the two groups of workers. Two groups of workers in the blood lead levels, and differences between the two groups of data. Results The single-ear hearing thresholds of the observation group were significantly higher at 4 and 6 k Hz than those of the control group (P <0.05). The blood lead concentrations in the observation group and the control group were (1.9 ± 0.7) and (0.8 ± 0.2) μmol / L, respectively, the difference was statistically significant (P <0.01). The contents of SOD in the observation group and the control group were 67.2 ± 15.3 and 64.7 ± 13.6, U / ml, there was no significant difference between the two groups (P> 0.05). The contents of MDA in serum of observation group and control group were (7.31 ± 3.36) and (6.53 ± 2.78) μmol / The difference was statistically significant (P <0.05). Conclusion Lead has synergistic effect on hearing impairment of workers exposed to noise. Free radical damage may be one of the mechanisms.