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为探讨细胞因子与肝硬化形成的关系,对32例肝硬化患者外周血单个核细胞分泌的IL-1、IL-6和TNFα活性水平进行了检测。结果显示,肝硬化患者外周血单个核细胞所产生的IL-1、IL-6和TNFα活性水平较正常对照组显著增高,提示这些细胞因子可能参与了肝硬化的形成过程。
To investigate the relationship between cytokines and cirrhosis, the levels of IL-1, IL-6 and TNFα secreted by peripheral blood mononuclear cells from 32 patients with cirrhosis were detected. The results showed that the levels of IL-1, IL-6 and TNFα produced by peripheral blood mononuclear cells in patients with cirrhosis were significantly higher than those in normal controls, suggesting that these cytokines might be involved in the formation of cirrhosis.