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本文采用直接测定生物样品中超氧化物歧化酶(SOD)活性的极谱法,研究了家兔iv三种不同剂量和im高剂量SOD后的药代动力学以及小鼠ipSOD后的组织分布和尿粪排泄的特点.家兔iv和imSOD的血清SOD活性-时间数据符合线性二室开放模型,其t_(1/2β)分别为49.7,46.1,40.5和118.5 min,im生物利用度为72.0％。小鼠ip SOD后1～3 h,组织中的SOD活性以胆囊和胃为最高,然后依次为肌肉、肺、肝、脑和肾,而心脏和睾丸最低;由尿粪排泄的SOD活性甚少,24 h内的累积排泄量分别仅为给药剂量的1.48和0.45％。
In this paper, direct determination of biological samples by superoxide dismutase (SOD) activity of the polarographic method to study rabbit iv three different doses and high dose of SOD pharmacokinetics after ipSOD mice and tissue distribution and urine The characteristics of excretion of feces were as follows: The serum SOD activity-time data of rabbits iv and imSOD accord with the linear two-compartment open model with t 1/2 (1/2) β of 49.7, 46.1, 40.5 and 118.5 min respectively, and the bioavailability of im was 72.0%. SOD activities in the tissues were highest in the gallbladder and stomach, followed by muscle, lung, liver, brain and kidney, with the lowest in the heart and testes; SOD activity excreted by the urine excrement was very low , Cumulative excretion within 24 h were only 1.48 and 0.45% of the dose administered.