钙拮抗剂是一类能够阻止Ca~(++)通过细胞膜系统进入胞浆的结构不同的药物,1969年由Fleckenstein倡用。10余年来已有异搏停、甲基异搏停、硝苯吡啶、硫氮(艹卓)酮、心可定及双环已哌啶等数种。本文对其作用机理、药理作用及临床应用做一概述,并比较钙拮抗剂与β肾上腺素能受体阻滞剂的异同。 Calcium antagonists, a class of drugs that block the entry of Ca ~ (++) into the cytoplasm through the cell membrane system, were introduced by Fleckenstein in 1969. More than 10 years have been verapamil, methyl isostere, nifedipine, sulfur nitrogen (艹 Zhuo) ketone, heart can be fixed and bicyclic piperidine and other species. This article gives an overview of its mechanism of action, pharmacological effects and clinical applications, and compare the similarities and differences between calcium antagonists and β-adrenergic receptor blockers.