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目的了解东莞地区初发2型糖尿病(T2DM)患者脂酰肉碱代谢特点。方法收集107例初发T2DM患者血滤纸片标本,与正常对照组93例比较。应用串联质谱技术分析脂酰肉碱的含量。结果与正常对照组相比,T2DM患者血中游离肉碱的含量无明显改变,而长链脂酰肉碱(C14~C18)的含量增高,差异有统计学意义(P<0.05)。结论东莞地区新发T2DM患者存在长链脂酰肉碱的代谢异常。
Objective To understand the metabolic characteristics of carnitine in patients with type 2 diabetes mellitus (T2DM) in Dongguan area. Methods Totally 107 blood samples of newly diagnosed T2DM patients were collected and compared with 93 normal subjects. Analysis of acylcarnitine by tandem mass spectrometry. Results Compared with the normal control group, the content of free carnitine in blood of T2DM patients did not change significantly, while the content of long chain fatty acylcarnitine (C14 ~ C18) increased, with statistical significance (P <0.05). Conclusion There are metabolic abnormalities of long-chain carnitine in newly diagnosed T2DM patients in Dongguan.