地戈辛是临床广泛应用的洋地黄类药物,其治疗指数低,毒性反应发生率高,剂量较难掌握。从六十年代初开始,国外先后应用同位素示踪法和放射免疫分析法,研究正常及各种病理状态下的药物动力学,并借此指导临床,提高了合理用药水平,降低 Digoxin clinical digitalis is widely used drugs, the therapeutic index is low, the incidence of toxic reactions, dosage is more difficult to grasp. Since the early 1960s, foreign countries have applied isotope tracing and radioimmunoassay to study the pharmacokinetics under normal and various pathological conditions and to guide clinical practice, thus raising the level of rational drug use and reducing