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依拉地平(laradipine)属二氢吡啶钙阻滞剂,其化学式与尼卡地平和硝苯啶相关,近来,FDA准予口服治疗高血压。药理:依拉地平可从胃肠道迅速吸收,大量经首次代谢。约1.5小时可达血药峰值。本药及其代谢物主要经尿排泄,终末半衰期约8小时。象尼卡地平(Nicardipine)和硝苯啶一样,依拉地平是一种作用比维拉帕米(Verapamil)或硫氮(艹卓)酮(Diltiazem)更强的血管扩张剂。反射性心动过速的作用很弱,一般不增加心肌耗氧量。临床研究:许多对照试验表明,依拉地平治疗高血压与噻嗪类利尿剂,β-阻滞剂或其他钙通道阻滞剂荆一样有效。剂量:本药的推荐量是每天两次,每次2.5～5mg。用于肾功能不全,肝疾病或老年患者不必调整剂量。副作用:依拉地平较维拉帕米更少引起便秘,但
Laradipine is a dihydropyridine calcium blocker whose chemical formula is related to nicardipine and nifedipine. Recently, the FDA granted oral treatment of hypertension. Pharmacology: Eradipine can be quickly absorbed from the gastrointestinal tract, a large number of first-time metabolism. About 1.5 hours up to the blood peak. The drug and its metabolites mainly excreted by urine, the terminal half-life of about 8 hours. Like nicardipine and nifedipine, eradipine is a vasodilator that acts more strongly than Verapamil or Diltiazem. The role of reflex tachycardia is weak, generally do not increase myocardial oxygen consumption. Clinical Studies: Many controlled trials have shown that treatment of hypertension with isradipine is as effective as thiazide diuretics, beta-blockers or other calcium channel blockers. Dosage: The recommended amount of the drug is twice daily, each 2.5 ~ 5mg. For renal insufficiency, liver disease or elderly patients do not have to adjust the dose. Side effects: Eradipine causes less constipation than Verapamil, however