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目的:探讨血清可溶性肿瘤坏死因子样弱凋亡诱导因子(sTWEAK)、B型利钠肽(BNP)、基质金属蛋白酶1(MMP-1)水平与扩张型心肌病(DCM)患者左心室重构的相关性。方法:选取陆军第七十二集团军医院2018年11月至2019年11月收治的DCM患者106例作为研究对象，同期选取体检健康人员70例作为健康对照组，分别测定血清sTWEAK、BNP、MMP-1水平，采用超声心动图测定左室舒张末期内径(LVEDD)、左室射血分数(LVEF)、左室质量指数(LVMI)。对血清学各指标与患者左心室重构的关系行Pearson相关性分析。结果:DCM组心功能Ⅱ、Ⅲ级与健康对照组在LVEDD、LVEF、LVMI、血清sTWEAK、BNP、MMP-1水平比较差异均有统计学意义(n F＝1 447.751、208.642、147.46、55.742、319.916、205.741，均n P<0.05)。与DCM组心功能Ⅱ级比较，心功能Ⅲ级DCM患者LVEDD、LVMI、BNP、MMP-1水平更高，LVEF更低，差异均有统计学意义(n t＝17.702、19.308、7.279、24.511、5.129，均n P<0.05)。血清sTWEAK与LVEDD和LVMI呈负相关(n r＝－0.221、－0.462，均n P<0.05)，与LVEF呈正相关(n r＝0.490，n P<0.05)；BNP水平与LVEDD和LVMI呈正相关(n r＝0.667、0.483，均n P<0.05)，MMP-1水平与LVEDD和LVMI呈正相关(n r＝0.756、0.562，均n P<0.05)，BNP、MMP-1水平均与LVEF呈负相关(n r＝－0.476、－0.404，均n P<0.05)。n 结论:血清sTWEAK水平在DCM患者中降低，BNP、MMP-1水平在DCM患者中升高，三种指标均能反映患者左室重构的严重程度。“,”Objective:To explore the relationship between the levels of serum sTWEAK, BNP, MMP-1 and left ventricular remodeling in patients with dilated cardiomyopathy(DCM).Methods:From November 2018 to November 2019, 106 DCM patients admitted to Army No.72 Group Military′s Hospital were selected as DCM group, and 70 non-DCM peoplewho received physical examination at the same time were selected as control group.The serum levels of sTWEAK, BNP and MMP-1 were measured respectively, and LVEDD, LVEF and LVMI were measured by echocardiography.Pearson correlation analysis was carried out on the relationship between serological indicators and left ventricular remodeling.Results:There were statistically significant differences between the DCM group and the control group in ultrasonic index, serum sTWEAK, BNP and MMP-1 levels(n F=1 447.751, 208.642, 147.46, 55.742, 319.916, 205.741, all n P<0.05). Compared with the DCM group with heart function grade Ⅱ, the levels of LVEDd, LVMI, BNP, MMP-1 were higher and LVEF was lower in the DCM group with heart function grade Ⅲ(n t=17.702, 19.308, 7.279, 24.511, 5.129, all n P<0.05). The serum sTWEAK was negatively correlated with LVEDD and LVMI(n r=-0.221, -0.462, all n P<0.05), and positively correlated with LVEF(n r=0.490, n P<0.05). The BNP level was positively correlated with LVEDd and LVMI(n r=0.667, 0.483, all n P<0.05). The MMP-1 was positively correlated with LVEDd and LVMI(n r=0.756, 0.562, all n P<0.05). The BNP and MMP-1 were negatively correlated with LVEF(n r=-0.476, -0.404, all n P<0.05).n Conclusion:The serum level of sTWEAK decreased in DCM patients, while BNP and MMP-1 increased in DCM patients.All three indicators can reflect the severity of left ventricular remodeling.