目的　通过观察新生血管生长发育与成型过程的形态学变化 ,研究青蒿琥酯对新生血管形成的影响。　方法　采用鸡胚绒毛尿囊膜模型、大鼠主动脉环无血清培养及人脐静脉内皮细胞体外培养 ,检测青蒿琥酯在新生血管形态发育过程中的作用。　结果　青蒿琥酯可影响血管内皮生长与实心条索形成 ,使血管生长期明显滞后 ,抑制血管生长。　结论　青蒿琥酯能通过干扰血管生长发育与成型而抑制血管生成。 Objective To study the effect of artesunate on the formation of neovascularization by observing the morphological changes in the growth and development of neovascularization and the shaping process. Methods The chicken embryo chorioallantoic membrane model, serum-free culture of rat aortic rings and culture of human umbilical vein endothelial cells in vitro were used to detect the role of artesunate in the development of neovascularization. Results Artesunate can affect the growth of vascular endothelium and the formation of solid cords, which can delay the growth of blood vessels and inhibit the growth of blood vessels. Conclusion Artesunate can inhibit angiogenesis by interfering with the growth and development of blood vessels.