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[目的]探讨慢性肝炎患者肝功能、胃泌素和胃动素表达在胃黏膜损伤中的临床意义。[方法]收集2013年5月~2015年7月我院消化内科诊治的慢性肝炎患者126例。电子胃镜检查胃黏膜损伤,ELISA法检测ALT和AST肝功能指标,放射免疫法检测胃泌素、胃动素表达。[结果]轻度、中度和重度慢性肝炎患者胃黏膜损伤的胃镜检出率分别为94.7%(36/38)、96.2%(50/52)和97.2%(35/36),各组之间差异无统计学意义(P>0.05)。但胃黏膜损伤程度表明,轻度、中度和重度慢性肝炎患者之间胃黏膜损伤程度差异有统计学意义,胃黏膜损伤程度与临床分级呈显著正相关(r=0.416,P<0.05)。不同程度胃黏膜损伤患者之间ALT和AST肝功能指标以及胃泌素和胃动素表达差异有统计学意义(P<0.05)。其中重度患者高于中度患者(P<0.05),中度患者又高于轻度患者(P<0.05)。[结论]慢性肝炎患者的肝功能损伤、胃泌素和胃动素高表达参与了胃黏膜病变的形成。
[Objective] To investigate the clinical significance of liver function, gastrin and motilin expression in gastric mucosal injury in patients with chronic hepatitis. [Methods] A total of 126 patients with chronic hepatitis treated in our department from May 2013 to July 2015 were collected. Electrogastroscopy was used to detect gastric mucosal injury, ALT and AST were measured by ELISA, and gastrin and motilin were detected by radioimmunoassay. [Results] The detection rates of gastric mucosal lesion in patients with mild, moderate and severe chronic hepatitis were 94.7% (36/38), 96.2% (50/52) and 97.2% (35/36), respectively There was no significant difference between the two groups (P> 0.05). However, the degree of gastric mucosal injury showed that there was significant difference in the degree of gastric mucosal injury among patients with mild, moderate and severe chronic hepatitis. There was a significant positive correlation between gastric mucosal injury and clinical grade (r = 0.416, P <0.05). The ALT and AST indexes of liver function and the expressions of gastrin and motilin in patients with different degrees of gastric mucosal injury were significantly different (P <0.05). Among them, severe patients were higher than moderate ones (P <0.05), moderate ones were higher than mild ones (P <0.05). [Conclusion] Hepatic injury, high expression of gastrin and motilin in chronic hepatitis patients are involved in the formation of gastric mucosal lesions.