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为探讨血清可溶性细胞间粘附分子1(sICAM-1)与胃癌转移的关系,采用酶联免疫吸附法测定了健康献血员48份、早期胃癌16份和进展期胃癌26份血清sICAM-1浓度。结果表明进展期胃癌sICAM-1为11.724±33.766mg/L,显著高于早期胃癌(0.758±0.364mg/L)和正常对照(0.558±0.272mg/L),早期胃癌亦高于正常对照。sICAM-1动态观察发现,肿瘤未完全切除或复发者血清slCAM-1浓度仍较高。提示sICAM-1与胃癌或胃癌转移有关。
To investigate the relationship between serum soluble intercellular adhesion molecule-1 (sICAM-1) and metastasis of gastric cancer, 48 serum levels of healthy blood donors, 16 early gastric cancers, and 26 advanced gastric cancers were determined by enzyme-linked immunosorbent assay. . The results showed that the advanced gastric cancer sICAM-1 was 11.724±33.766mg/L, which was significantly higher than that of early gastric cancer (0.758±0.364mg/L) and normal control (0.558±0.272mg/L). The early gastric cancer was also higher than the normal control. Dynamic observation of sICAM-1 revealed that the concentration of serum slCAM-1 was still high in patients with incomplete resection or recurrence. It is suggested that sICAM-1 is related to gastric cancer or gastric cancer metastasis.